NFKB1 and neoplasm: Lastly, DAB2IP (Disabled homolog 2–interacting protein) is a tumor suppressor that restrains PI3K–AKT, NF-κB, and ERK signaling, regulating apoptosis, epithelial–mesenchymal transition (EMT), and invasion across various cancers, including prostate, colorectal, and gastric [31,32,33].