Extending this context dependence beyond melanoma, Zhang et al. concluded that in colon adenocarcinoma, higher LRP2 expression correlates with worse prognosis and higher pathological stage, and that forced LRP2 overexpression increases proliferation in COAD cell lines, again illustrating that tumors can either lose LRP2 (with dedifferentiation) or co-opt it to support growth, depending on tissue context-a pattern contrasting with our ocular tumor data [51]. This evidence concerns the gene LRP2 and colon adenocarcinoma.