This pattern aligns with DAB2IP’s tumor-suppressor role, where its repression (epigenetic/microRNA) unleashes ERK/AKT/NF-κB signaling, proliferation, EMT, and resistance to apoptosis, while preserved expression in epithelioid melanoma suggests a reliance on alternative oncogenic programs. This evidence concerns the gene NFKB1 and epithelioid cell melanoma.