Soluble fibrin–fibronectin complexes have been shown to activate integrin αvβ3 on THP-1 macrophages, suggesting that integrin activation by fibrin–fibronectin is a function that macrophages have in common with tumor cells that invade clotted plasma in order to induce metastasis to the lungs [12,14]. The gene discussed is FN1; the disease is neoplasm.