As the combination of IL-1 and IL-6 treatments enhanced intracellular signaling (Figure 1 and Figure S1) and cytostasis (Figure 2 and Figure S2) in the C4-2 and LNCaP PCa parental cell lines, we wanted to determine if chronic IL-1 exposure alters IL-1/IL-6 crosstalk. This evidence concerns the gene IL1B and posterior cortical atrophy.