CCND2 and lymphoma: Its compatibility with FFPE specimens is particularly valuable in lymphoma diagnostics, where complex rearrangements such as fusions involving CCND2, T-cell receptor (TCR), and immunoglobulin (IG) heavy and light chains are challenging to detect due to the limited availability of targeted FISH probes and the absence of fusion/chimeric transcripts detectable by RNA sequencing (Figure 4E).