CD274 and neoplasm: The DCVax-L-induced T-cell infiltration in the brain can shift the tumor microenvironment from a “cold” immunosuppressive (dominated by Tregs, M2 macrophages, and PD-L1 expression) toward a more “hot” pro-inflammatory, immune-active state, thereby enhancing antigen spreading characterized by memory immune responses against additional tumor antigens released during tumor lysis.