Functionally, it influences multiple cancer-relevant pathways, including PI3K/AKT/mTOR signaling, immune evasion mechanisms, mismatch repair regulation, enhancer of zeste homolog 2 (EZH2)-mediated methylation, steroid receptor signaling, DNA damage checkpoints, p53 target regulation, and KRAS-driven transcriptional networks [136]. This evidence concerns the gene EZH2 and cancer.