These findings align with our earlier observations [50] of the essential role of CD4+ T-cell-activated DCs for optimal CD8+ T-cell-mediated killing of autologous tumors based on three cell-type interactions in two steps: in the first step, DCs activate CD4+ T cells by presenting the tumor peptides in the context of their MHC class II molecules. The gene discussed is CD8A; the disease is neoplasm.