Ding et al. [80] showed that CXCL13-dependent recruitment of CXCR5+ B cells into TLS located within or adjacent to the TME plays a crucial role in presenting tumor antigens to Tfh and CXCL13+ CD8+ cytotoxic T cells in melanoma patients receiving ICI therapy, thereby improving survival probability. This evidence concerns the gene CXCL13 and melanoma.