In a similar analysis by Switlyk et al. [78] in 45 patients, low PTEN expression correlated with greater tumor aggressiveness: higher Gleason score (p = 0.028), lymph node metastases (21% vs. 3%, p = 0.008), and extraprostatic extension (47% vs. 17%, p = 0.048). This evidence concerns the gene PTEN and neoplasm.