RNA-seq analysis showed that several genes, DNMT1, CDK1, MKI67, CDC20, AURKA, UBE2C, PDGFB, and PLK1, previously positively correlated with the progression of PCa, are markedly downregulated upon SBFI-103 and SBFI-1143 treatment [40]. The gene discussed is PLK1; the disease is posterior cortical atrophy.