At the same time, highly downregulated genes, such as the RNA component of 7SK nuclear ribonucleoprotein (RN7SK), FAM111 trypsin-like peptidase B (FAM111B), Phosphatase and actin regulator 3 (PHACTR3), Ribonucleotide reductase regulatory subunit M2 (RRM2), Adhesion G protein-coupled receptor F1 (ADGRF1), Hyaluronan synthase 3 (HAS3), Mitochondrially encoded cytochrome c oxidase II (COX2), and DNA topoisomerase II alpha (TOP2A), are involved in positive regulation of cell proliferation, cell cycle progression, and tumor growth. The gene discussed is TOP2A; the disease is neoplasm.