At the same time, highly downregulated genes, such as the RNA component of 7SK nuclear ribonucleoprotein (RN7SK), FAM111 trypsin-like peptidase B (FAM111B), Phosphatase and actin regulator 3 (PHACTR3), Ribonucleotide reductase regulatory subunit M2 (RRM2), Adhesion G protein-coupled receptor F1 (ADGRF1), Hyaluronan synthase 3 (HAS3), Mitochondrially encoded cytochrome c oxidase II (COX2), and DNA topoisomerase II alpha (TOP2A), are involved in positive regulation of cell proliferation, cell cycle progression, and tumor growth. This evidence concerns the gene FAM111B and neoplasm.