Among covariates in the final combined model, older age (HR = 1.12, p < 0.001), years of education (HR = 1.05, p = 0.032), APOE4 carrier status (HR = 1.57, p = 0.008), and lower openness to experience (HR = 0.96, p = 0.007) were significantly associated with increased dementia risk. Here, APOE is linked to dementia.