PKP2 and familial dilated cardiomyopathy: Furthermore, Saxton et al. [35] and Lorca et al. [36] emphasize the recurrent involvement of RBM20, MYH7, SCN5A, and PKP2 in DCM, particularly the RBM20 p.Arg636Cys variant, which has been linked to a high risk of sudden cardiac death even in subclinical presentations.