Notably, sarcomeric genes such as TNNI3, TNNT2, MYBPC3, and MYH7 are classically associated with HCM, but the findings obtained by the present review demonstrate their significant role in DCM as well, establishing them as shared genetic substrates between the two cardiomyopathies [23,26,33,34,35,36]. The gene discussed is TNNI3; the disease is cardiomyopathy.