On the nuclear genome side, Elliot et al. [25] reported a range of missense and splicing mutations in desmosomal genes, including PKP2 (S140F and H877Q) and DSP (IVS15–1G>C and A2712T), alongside variants of uncertain significance such as V56M (DSG2) and G863R (DSC2), typically found in cases of arrhythmogenic right ventricular cardiomyopathy reported in literature (ARVC). Here, DSC2 is linked to Arrhythmogenic right ventricular dysplasia.