In our study, we found that the most frequently represented mutations in DCM span a wide array of genes involved in mitochondrial function (mtDNA), sarcomeric integrity (TTN, MYBPC3, and TNNT2), cytoskeletal architecture (FLNC and BAG3), and intercellular adhesion (DSP and PKP2), reflecting the complex and multifactorial nature of the disease [23,24,25,26,27,28,29,30,31,32,33,34,35,36]. Here, PKP2 is linked to familial dilated cardiomyopathy.