F2 and acute promyelocytic leukemia: A review of studies from 1989 to 2019 identified potential predictors of bleeding in APL patients—including white blood cell count, blast percentage, lactate dehydrogenase (LDH), platelet count, fibrinogen, D-dimer, prothrombin time (PT)/international normalized ratio (INR), activated partial thromboplastin time (aPTT), creatinine, performance status, and differentiation syndrome [2].