Similarly, Schaefer et al. devised a pyrexia score algorithm combining C-reactive protein (CRP), LDH, leukocyte, and platelet counts; they showed that this score differentiated patients who developed pyrexia, and that systemic biomarker shifts (e.g., increase in CRP, fall in leukocytes/platelets) correlated with the inflammatory response induced by therapy [48,49]. This evidence concerns the gene CRP and Fever.