Both patients presented with a hyper-enhancing right renal mass suspicious for clear cell renal carcinoma (ccRCC) and subsequently underwent both 18F-FDG and 68Ga-NY104 PET/CT, with histopathology and CAIX immunohistochemistry (IHC) as the reference standard. The gene discussed is CA9; the disease is nonpapillary renal cell carcinoma.