The resulting model explained 29.9% of the variances in the diagnosis of significant CAD (Nagelkerke R2 = 0.299) and 41.6% in the diagnosis of left main disease (Nagelkerke R2 = 0.416), apoB remaining significant in both cases (OR 2.506, 95% CI 1.458–4.308, p = 0.000; OR 4.792, 95% CI 1.574–14.585, p = 0.006, respectively). The gene discussed is APOB; the disease is coronary artery disorder.