TNFRSF10A and celiac disease: Genetically, the disease has a close association with the human leukocyte antigen (HLA) DR3-DQ2 and/or DR4-DQ8 gene locus, with over 99% of individuals with celiac disease having the HLA DR3-DQ2 and/or DR4-DQ8 allele, compared with 30–40% of the general population [36,37].