Compared with AD tumors, AYA tumors showed higher expression of CXCR4 (p = 0.040), S100A2 (p = 0.037), and OPCML (p = 0.038), and lower expression of IL-1β (p < 0.001), CHL1 (p = 0.027), ATP1A3 (p = 0.048), and HLA-DRA (p = 0.026). Here, CHL1 is linked to Alzheimer disease.