A meta-analysis of 10 randomized clinical trials evaluating the effects of low-GI/glycemic load diets vs. high-GI/GL diets on body weight, fasting glucose, lipid profile, and insulin concentration revealed that individuals with obesity on low-GI/GL diets achieved greater body weight reductions, fasting glucose, and insulin levels than those on high-GI/GL diets. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.