CAMK2G and hypertensive disorder: In hypertension, TMAO activates protein kinase RNA-like endoplasmic reticulum kinase (PERK) and downstream ROS-CaMKII-PLCβ3-Ca2+ pathways (reactive oxygen species (ROS), calmodulin-dependent protein kinase (CaMKII), phospholipase C β3 and intracellular calcium (Ca2+)) [111].