LYZ and colitis: This host-specific response divergence mechanistically aligns with lysozyme’s dual roles in colitis models [35,37]—where enzyme source variation (human rhLYZ vs. avian HEWL) and host microbiota baseline features (Firmicutes vs. Bacteroidetes predominance) jointly modulate metabolic efficiency (butyrate production) and immune tolerance thresholds, ultimately determining the biological trajectory of lysozyme effects.