In the PC setting, antioxidant and DS use, such as Vitamins C, D, and E, among others, has not been found to affect prostate-specific antigen (PSA) levels, making their impact on PC risk unclear, and ultimately, producing inadequate results to recommend the use of DSs in PC [31].Despite establishing patterns of use and identifying common DSs used by cancer survivors, understanding the clinical implications of these behaviors remains challenging. The gene discussed is KLK3; the disease is cancer.