Specific disrupted “histone codes” in OC include OGA, an O-GlcNAcase that modulates histone acetylation indirectly via O-GlcNAcylation crosstalk (influences p53 stability), NCOA3 (a co-activator linked to platinum resistance), BRD4 (a reader that enhances transcription and can be targeted by inhibitors), and erasers such as SIRT2, HDAC1, HDAC4, and HDAC11, whose altered activities influence drug sensitivity, tumor progression, and survival [108]. This evidence concerns the gene OGA and neoplasm.