KDM6A and neoplasm: Another contributing factor is the histone demethylase Kdm6a (Utx), a potential tumor suppressor, whose deletion in the paternal germline develop to extensive H3K27me3 redistribution, enhancer hypermethylation, and altered transcription factor binding in offspring somatic tissues, correlating with increased tumor incidence and reduced survival effects that are amplified by successive generations of Kdm6a loss [75].