As a preliminary, small-sample pilot study, our findings provide early evidence supporting the beneficial role of a simple and well-tolerated dietary modification—replacing one daily serving of starchy carbohydrates with 200 g of vegetables from the Brassicaceae and Asteraceae families—in significantly reducing serum autotaxin (ATX) levels in individuals with obesity and MASLD. The gene discussed is ENPP2; the disease is obesity due to melanocortin 4 receptor deficiency.