This pilot study provides new evidence that a short-term, vegetable-enriched dietary intervention—based on the simple substitution of one daily portion of starchy carbohydrates with 200 g of vegetables from the Brassicaceae and Asteraceae families—can significantly reduce serum autotaxin (ATX) levels in individuals with obesity and MASLD. This evidence concerns the gene ENPP2 and obesity due to melanocortin 4 receptor deficiency.