The non-IgE-mediated allergy is subclassified into three entities/subtypes: Food Protein-Induced Allergic Proctocolitis (FPIAP), referred to in our study as Allergic Proctocolitis (AP), Food Protein-induced Enteropathy (FPE), and Food Protein-Induced Enterocolitis Syndrome (FPIES). Here, IGHE is linked to allergic disease.