Based on the ES measure, it was observed that the activation of PBLs ex vivo was significantly higher in the AD group, which exhibited a greater average increase in cytokine release—TNF-α (U = 311; p = 0.001; p(BH) = 0.002; rG = −0.39), IL-1β (U = 289; p < 0.001; p(BH) = 0.001; rG = −0.43), IL-6 (U = 296; p < 0.001; p(BH) = 0.001; rG = −0.42), and IL-10 (U = 340; p = 0.003; p(BH) = 0.005; rG = −0.35)—compared to the control group. This evidence concerns the gene IL6 and Alzheimer disease.