Moreover, it was demonstrated that miR-17 drives CRC aggressiveness via a self-reinforcing cancer-associated fibroblast (CAF)-tumor loop: exosomal miR-17 activates RUNX3/MYC/TGF-β1 signaling, hyperactivating CAFs to enhance oncogenic signaling and promote metastasis [13]. The gene discussed is TGFB1; the disease is colorectal carcinoma.