POLR2A and colorectal carcinoma: Among the key targets evaluated in this study are well-studied proteins in CRC and associated diseases, including ALDH2 and SKP2, moderately to poorly characterized proteins in CRC pathogenesis, such as DNM2, ATIC, POLR2A, GLUD2, RPL17, UQCRC1, and UQCRC2, as well as uncharacterized targets, including WDR61, ACAA1, RPS2, RPL27, RPS23, RPS4X, PSMD5, MAGOH, and MAGOHB (Table 1).