For comprehensive coverage of specific RACK1 functions, we direct readers to specialized reviews cited throughout this article, covering its roles in: signaling and cellular dynamics [1,15,28,65]; centrosome organization [38]; ribosome association [3]; stress granules and neuronal translation [95]; cancer [16]; nervous system development [84]; Alzheimer’s disease [20]; and viral infection [73]. This evidence concerns the gene RACK1 and early-onset autosomal dominant Alzheimer disease.