In mouse neuroblastoma-derived NS20Y cells, DEHP exposure reduced the mRNA and protein expression of PI3K and AKT, concomitantly increasing the mRNA and protein expression of Cyt-c, Bax, Bak, and Caspase-3, while decreasing the mRNA and protein expression of Bcl-2 [44]. The gene discussed is BCL2; the disease is neuroblastoma.