For instance, in small-cell lung cancer, miR-1 directly suppresses C-X-C motif chemokine receptor 4 (CXCR4), leading to the subsequent inhibition of FOXM1 and ribonucleotide reductase M2 (RRM2), thereby impeding tumor progression [27]. The gene discussed is CXCR4; the disease is small cell lung carcinoma.