Last, but not least, there is growing evidence that CXCL9/CXCL10/CXCR3 and CXCL16/CXCR6 are involved in tumor pathogenesis, so they probably represent pleiotropic chemokines at the crossroads of immunity and carcinogenesis [28,62,63]. This evidence concerns the gene CXCL9 and neoplasm.