KLF4 also modulates PCD pathways: it counteracts oxidative stress, restores autophagy in hyperhomocysteinemia-induced VSMC dysfunction [34,38], inhibits ferroptosis by upregulating glutathione peroxidase 4 (GPX4) and solute carrier family 7 member 11 (SLC7A11) [39], and transcriptionally represses NLRP3 by binding to its promoter [40]. The gene discussed is GPX4; the disease is hyperhomocysteinemia.