Atherosclerosis progression can be driven by impaired cholesterol efflux, lipid accumulation, and chronic inflammation, while KLF14 arises as a critical regulator of cholesterol metabolism, enhancing the expression of the cholesterol efflux transporter, ATP-binding cassette transporter A1 (ABCA1), to attenuate atherosclerosis. Here, ABCA1 is linked to atherosclerosis.