Moreover, it was reported that Insulin-Like Growth Factor Binding Protein 1 (IGFBP1) and Insulin Receptor Substrate 2 (IRS2) genes, members of the insulin/IGF-1 pathway, were hypermethylated in the high-BMI BE patients compared to the low-BMI cases. The gene discussed is IGFBP1; the disease is Barrett esophagus.