WFDC2 and ovarian carcinoma: In addition, certain proteins, such as WFDC2 (also known as HE4) (WAP four-disulfide core domain protein 2/Human Epididymis Protein 4—used in triaging or early diagnosis of ovarian cancer) or KRT19 (keratin 19, a protein that is part of the intermediate filament system and helps maintain the structural integrity of epithelial cells) are highly sensitive and specific in differentiating malignant from benign lesions, and their associations can be successfully used in predictive models to support the diagnostic process [232,233,234,235].