The mT3 cell number after growth in co-culture with wild-type PSC was 36% greater than mT3 co-cultured with CCK-BR-KO PSC (Figure 2C, green column; p < 0.05), suggesting that the CCK-BR expression on PSC is in part responsible for the proliferative effect on PDAC cells in the tumor microenvironment and influences the cross-communication between the stellate cells and the cancer cells. The gene discussed is CCKBR; the disease is cancer.