Further supporting that EGF may be protective of AD, a study of single brain endothelial cell cultures and triple cultures (endothelial cells, astrocytes, and pericytes) mimicking a microvascular unit with oligomeric Aβ1–42 results in decreased angiogenesis and increased vessel disruption; however, EGF treatment prevented this effect, suggesting its use as a potential therapeutic for AD [95]. The gene discussed is EGF; the disease is Alzheimer disease.