Other relatively recent studies have shown that brain-derived p-Tau more specifically correlates with Tau-PET and cognition compared to t-Tau [18], or that Tau microtubule-binding region (MTBR) containing the residue 243 (MTBR-tau243) can better detect insoluble Tau aggregates compared to common p-Tau measures later in more advanced stages of AD [22], suggesting that additional studies to determine which specific Aβ and Tau peptides can best detect AD pathology may also be beneficial. This evidence concerns the gene MAPT and Alzheimer disease.