Other proteins identified by at least three of the six models tested include IL-3, IL-11, M-CSF/CSF1, TNF-α, IL-1RA/IL1RN, CKβ-8-1/CCL23, G-CSF/CSF3, IL-1β, and I-TAC/CXCL11, which also had previous studies demonstrating their potential role in AD outcome (see Supplementary Table S7). This evidence concerns the gene IL1RN and Alzheimer disease.