In the postmortem brains of AD patients, it was also upregulated, compared to controls [84], along with TIE-2, notably in endothelial cells, as well as altered in BA7 tissue homogenate expression, depending on Braak stages, as with TIE-2 [85], further showing that cerebrovasculature and BBB dysregulation due to ANG-2:TIE-2 signaling is mechanistically relevant. Here, ANGPT2 is linked to Alzheimer disease.