Given the known importance of aging as a major risk factor for AD, we evaluated how each biomarker identified may be related to aging by evaluating overlaps with previously published blood aging clock models or found to be differentially regulated by aging, based on the DNA methylome [62,63,64,65], transcriptome [66], and proteomics [67,68,69,70,71], or included in the Human Ageing Genomic Resources (HAGR) database (GenAge, CellAge, and cell senescence signatures) [72,73]. Here, CLOCK is linked to Alzheimer disease.