KEGG pathway terms related to various signaling cascades related to cytokine and inflammatory responses, and cell proliferation and survival, including MAPK, phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT), Janus kinase/signal transducer and activator of transcription (JAK/STAT), Ras-related protein 1 (Rap1), Ras and TNF signaling were identified, as well as terms related to cytokines, rheumatoid arthritis, and hematopoietic cell lineage. The gene discussed is AKT1; the disease is rheumatoid arthritis.