In this study, we comprehensively examined the expression patterns, regulatory mechanisms, and potential functional relevance of SOX family transcription factors—particularly SOX7, SOX17, SOX18, and SOX30—as well as their molecular interactors (MEF2C, VCAM1, and STAT3) in the context of non-small-cell lung cancer (NSCLC). The gene discussed is SOX18; the disease is non-small cell lung carcinoma.