The following search terms and combinations were used: “microbiota and psoriasis”; “nutrition and psoriasis”; “IL 17/23 axis and keratinocytes”; “NF-kb pathway and psoriasis”; “JAK-STAT pathway and psoriasis”; PI3K/Akt/mTOR pathway and psoriasis; “MAPK pathway and psoriasis”; “ROS and psoriasis”; “lipid peroxidation and psoriasis”; Sirtuin and psoriasis. The gene discussed is SOAT1; the disease is psoriasis.