The MAPK pathway is responsive to nutritional interventions; bioactive dietary compounds, including polyphenols, flavonoids, and antioxidants can suppress p38, ERK, and JNK phosphorylation, thus reducing IL-1β, IL-6, and S100 protein expression in KCs, thereby mitigating the inflammatory and hyperproliferative processes characteristic of psoriatic lesions [126,127]. The gene discussed is IL1B; the disease is dry eye syndrome.