SHBG and endometriosis: For example, in the work of Golovchenko et al., the relationship of GWAS-impact loci for the circulation level of SHBG (rs1641549 TP53 [54], rs727428 SHBG [52]) was shown only in their intergenic interactions (pronounced endometriosis-significant main effects of these loci were not detected) [60]; in the work of Garitazelaia et al. (the Mendelian randomization (MR) method was used in data analysis), it was not possible to identify causal relationships between sex hormones (including SHBG) and endometriosis [61].