The endometriosis risk allele G rs440837 reduces affinity for the TF Hoxa9 (the difference in the “LODscores” parameter of the G and A alleles was −1.7) and increases sensitivity to TFs Hlx1 and Smad3 (differences in the “LODscores” of the G and A alleles are 1.5 and 7.5, respectively). Here, SMAD3 is linked to endometriosis.