According to Figure 3 (it is a network of paired interactions that form TFs and proteins functionally related to rs440837 (A > G) ZBTB10 and 5 proxy SNPs), the following TF paired interactions demonstrate the greatest contribution to endometriosis susceptibility: SMAD3-MYC (coefficient [score] of the protein interaction −0.993), TGIF1-SMAD3 (0.974), MYC-CTCF (0.763), SOX4-MYC (0.722) and CTCF-SMAD3 (0.702). This evidence concerns the gene SMAD3 and endometriosis.