Thus, the results obtained indicate the important role of endometriosis-significant protein interactions of 22 TFs and protein products of 3 genes “dependent” on the rs440837 (A > G) ZBTB10 and 5 LD SNPs, mainly in the development of the endocrine system, regulation of gene transcription processes, the TGF-beta signaling pathway, regulation of cell proliferation/differentiation, etc. This evidence concerns the gene ZBTB10 and endometriosis.