NF-κB promotes tumor invasion and metastasis by transcriptional activation of matrix metalloproteinases (e.g., MMP-9) and pro-metastatic chemokines such as CXCL8, which collectively remodel the extracellular matrix, promote epithelial–mesenchymal transition, and enhance peritoneal implantation capacity. Here, NFKB1 is linked to neoplasm.