In vitro and in vivo (mouse model) studies led to the conclusion that this effect was due to blockade of the AKT/Gsk3β kinase signaling pathway and activation of the Hippo tumor suppressor pathway, which reduced the expression of the YAP effector protein and connective tissue growth factor (CTGF) in colon cancer cells. The gene discussed is CCN2; the disease is colonic neoplasm.