Pristimerin, another naturally occurring triterpenoid, has been shown to inhibit the proliferative activity of OVCAR-5, MDAH-2774, OVCAR-3, and SK-OV-3 ovarian cancer cells and induce the intrinsic apoptosis pathway by suppression of prosurvival signaling proteins, like p-AKT, p-mTOR, and NF-κB. The gene discussed is AKT1; the disease is ovarian cancer.