CD274 and neoplasm: NF-κB profoundly shapes the tumor microenvironment: it induces a pro-inflammatory secretome able to reprogram stromal and immune compartments toward a tumor-supportive phenotype, concomitantly with establishing an immuno-evasive microenvironment, e.g., by releasing programmed death-ligand 1 (PD-L1), a factor attenuating anti-tumor T-cell responses [98].