A crossover study using bioavailability-enhanced CBD (DehydraTECH) reported selective reductions in IL-8, IL-10, and IL-18 associated with blood pressure responses, but IL-1β and IL-6 decreased similarly after placebo, suggesting selective patterns and the need for replication and PK–PD linkage [35]. This evidence concerns the gene CXCL8 and Parkinson disease.