Morissette et al. (2021) [6] high-dose CBD (800 mg/day, 92 days) in subjects with a cocaine-use disorder: The CBD group presented with significantly lower IL-6 and VEGF-A versus placebo, as well as improved CD25+CD4+ regulatory T cells; no changes were detected in total B cells, CD4+ T cells, or CD8+ T cells. This evidence concerns the gene CD8A and cocaine use disorder.