Innate immune cells, such as mature dendritic cells and M1-tumor-associated macrophages (TAM), produce cytokines (IFN-α, IL-12, IL-18, or TNF-α) and chemokines (CXCL9, CXCL10, or CCL21) that suppress tumor angiogenesis. This evidence concerns the gene CXCL10 and neoplasm.