CHI3L1 and colorectal carcinoma: Hermunen et al. [49] demonstrated that in patients with radically treated CRC (stages II-IV) who underwent adjuvant 5-FU-based chemotherapy, postoperatively elevated CEA in combination with CA19-9 or YKL-40 or a normal CEA associated with an elevated YKL-40 may suggest a high risk of relapse.