On the receptor side, CNR1 (CB1; e.g., rs1049353) shows significant association with major depression [43], whereas evidence regarding CNR2 (CB2) is more nuanced, with no global case–control differences in panic disorder but a male-specific protective haplotype, alongside increased risk conferred by CNR1 variants in the same cohort [44]. The gene discussed is CNR2; the disease is major depressive disorder.