KEGG enrichment implicated axon guidance, FcεRI signaling, PI3K-Akt, Cushing syndrome, HIF-1 signaling and FcγR-mediated phagocytosis, suggesting that hypermethylation may repress pathways relevant to secretory activity in mammary epithelial cells. Here, AKT1 is linked to Cushing syndrome due to macronodular adrenal hyperplasia.