Further species-level verification and prognostic importance nominated three promising pairs: Paraburkholderia fungorum–TFAP2E in adrenocortical carcinoma (ACC), Actinomyces oris–TFAP2E in diffuse large B-cell lymphoma (DLBC), and Cutibacterium granulosum–TFAP2B in stomach adenocarcinoma (STAD). The gene discussed is TFAP2E; the disease is gastric adenocarcinoma.