Among these, five core programs were consistently identified across all cancers: Program 1 (ATF3, DDIT4, etc.), associated with stress; Program 2 (CD64, IFITM3, etc.), related to immune regulation; Program 3 (RPL10, RPL13A, etc.), linked to ribosome; Program 4 (COL1A1, LAMA3, etc.), indicative of metastasis; and Program 5 (CCNB1, MKI67, etc.), associated with proliferation. This evidence concerns the gene DDIT4 and cancer.