TAGLN2 and neoplasm: However, our results suggest that upregulation of TAGLN2 mRNA was correlated with worse prognosis in breast cancer patients and concurred with other studies, including gastric, colorectal, papillary thyroid, and endometrial cancers, whereby TAGLN2 is overexpressed and correlated with poor prognosis, advanced tumor stages, metastasis, and drug resistance [115,116,117,118].