There is a tumor suppressor role for SULF1, being an extracellular sulfatase that removes 6-O-sulfate groups from heparan sulfate (HS) chains, thereby reducing the activity of HS-binding growth factors such as FGF2, VEGF, amphiregulin, HB-EGF, and HGF [31]. The gene discussed is EGF; the disease is neoplasm.