Search terms included combinations of: “type 1 diabetes” OR “T1D” OR “autoimmune diabetes”, “TCR” OR “T cell receptor”, “antigen-specific”, “TCR-Treg” OR “regulatory T cell”, “tolerance induction”, “autoreactive T cell”, “insulin”, “GAD65”, “IA-2”, “ZnT8”, “hybrid insulin peptide” OR “HIP”, “TCR editing”. The gene discussed is SLC30A8; the disease is type 1 diabetes mellitus.