PML-NBs are dynamic nuclear structures composed of PML and non-PML structural proteins (Daxx, Sp100, ATRX, HDAC, HP1, SUMO-1, etc.)important for the regulation of genome organization and involved in several cellular processes such as DNA damage response, DNA repair, response to viral infection, apoptosis, protein modification, transcriptional regulation, cell proliferation, senescence and tumor suppression [83,84,91,92,93]. The gene discussed is PML; the disease is neoplasm.