In particular, Barba et al. reported a multicenter cohort of 47 patients with brain somatic SLC35A2 variants and featuring complex epileptic phenotype ranging from early epileptic encephalopathy (EE, 39 patients) with epileptic spasms to drug-resistant focal epilepsy (DR-FE, 8 patients) associated with normal/borderline cognitive function [38]. The gene discussed is SLC35A2; the disease is focal epilepsy.